The ADAM metalloproteinases
DR Edwards, MM Handsley, CJ Pennington - Molecular aspects of …, 2008 - Elsevier
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …
and secreted proteins with important roles in regulating cell phenotype via their effects on …
ADAM-17: the enzyme that does it all
M Gooz - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …
[PDF][PDF] MicroRNA‐122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma
WC Tsai, PWC Hsu, TC Lai, GY Chau, CW Lin… - …, 2009 - Wiley Online Library
MicroRNAs (miRNAs), which are inhibitors of gene expression, participate in diverse
biological functions and in carcinogenesis. In this study, we show that liver‐specific …
biological functions and in carcinogenesis. In this study, we show that liver‐specific …
Strategies to target ADAM17 in disease: from its discovery to the iRhom revolution
M Calligaris, D Cuffaro, S Bonelli, DP Spanò… - Molecules, 2021 - mdpi.com
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …
The roles of integrin α5β1 in human cancer
J Hou, D Yan, Y Liu, P Huang, H Cui - OncoTargets and therapy, 2020 - Taylor & Francis
Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …
health. Integrins are heterodimeric cell surface receptors that are composed by two non …
Gelatinase-mediated migration and invasion of cancer cells
M Björklund, E Koivunen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2005 - Elsevier
The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
Key metalloproteinase-mediated pathways in the kidney
J Wozniak, J Floege, T Ostendorf… - Nature Reviews …, 2021 - nature.com
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …
Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking
Mesenchymal stromal cells (MSCs) modulate immune cells to ameliorate multiple
inflammatory pathologies. Biophysical signals that regulate this process are poorly defined …
inflammatory pathologies. Biophysical signals that regulate this process are poorly defined …
The metalloprotease ADAM17 in inflammation and cancer
Proteolytic cleavage of transmembrane proteins is an important post-translational
modification that regulates the biological function of numerous transmembrane proteins …
modification that regulates the biological function of numerous transmembrane proteins …
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin
MD Sternlicht, SW Sunnarborg, H Kouros-Mehr, Y Yu… - 2005 - journals.biologists.com
Epithelial-mesenchymal crosstalk is essential for tissue morphogenesis, but incompletely
understood. Postnatal mammary gland development requires epidermal growth factor …
understood. Postnatal mammary gland development requires epidermal growth factor …