The ADAM metalloproteinases

DR Edwards, MM Handsley, CJ Pennington - Molecular aspects of …, 2008 - Elsevier
The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

ADAM-17: the enzyme that does it all

M Gooz - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor
necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an …

[PDF][PDF] MicroRNA‐122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

WC Tsai, PWC Hsu, TC Lai, GY Chau, CW Lin… - …, 2009 - Wiley Online Library
MicroRNAs (miRNAs), which are inhibitors of gene expression, participate in diverse
biological functions and in carcinogenesis. In this study, we show that liver‐specific …

Strategies to target ADAM17 in disease: from its discovery to the iRhom revolution

M Calligaris, D Cuffaro, S Bonelli, DP Spanò… - Molecules, 2021 - mdpi.com
For decades, disintegrin and metalloproteinase 17 (ADAM17) has been the object of deep
investigation. Since its discovery as the tumor necrosis factor convertase, it has been …

The roles of integrin α5β1 in human cancer

J Hou, D Yan, Y Liu, P Huang, H Cui - OncoTargets and therapy, 2020 - Taylor & Francis
Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …

Gelatinase-mediated migration and invasion of cancer cells

M Björklund, E Koivunen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2005 - Elsevier
The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …

Key metalloproteinase-mediated pathways in the kidney

J Wozniak, J Floege, T Ostendorf… - Nature Reviews …, 2021 - nature.com
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking

SW Wong, S Lenzini, MH Cooper, DJ Mooney… - Science …, 2020 - science.org
Mesenchymal stromal cells (MSCs) modulate immune cells to ameliorate multiple
inflammatory pathologies. Biophysical signals that regulate this process are poorly defined …

The metalloprotease ADAM17 in inflammation and cancer

S Düsterhöft, J Lokau, C Garbers - Pathology-Research and Practice, 2019 - Elsevier
Proteolytic cleavage of transmembrane proteins is an important post-translational
modification that regulates the biological function of numerous transmembrane proteins …

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

MD Sternlicht, SW Sunnarborg, H Kouros-Mehr, Y Yu… - 2005 - journals.biologists.com
Epithelial-mesenchymal crosstalk is essential for tissue morphogenesis, but incompletely
understood. Postnatal mammary gland development requires epidermal growth factor …