Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host
protein degradation, is a promising target to develop new treatments against sleeping …

Cysteine proteases play numerous indispensable roles in the biology of parasitic organisms.
Aside from previously known general catabolic functions and protein processing, cysteine …

Lysosomal cysteine proteases were believed to be mainly involved in intracellular protein
degradation. Under special conditions they have been found outside lysosomes resulting in …

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

The co-expression of MMPs and cysteine cathepsins in the human dentin-pulp complex
indicates that both classes of enzymes can contribute to the endogenous proteolytic activity …

The major histocompatibility complex (MHC) class II–associated invariant chain (Ii) regulates
intracellular trafficking and peptide loading of MHC class II molecules. Such loading occurs …