When assessing causal effects, determining the target population to which the results are
intended to generalize is a critical decision. Randomized and observational studies each …

Evidence for Health Decision Making — Beyond Randomized, Controlled Trials | NEJM Skip to
main content NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare …

Background: Spontaneous coronary artery dissection (SCAD) is the most common cause of
pregnancy-associated myocardial infarction and remains poorly characterized. Objectives …

Why a thoroughly updated and revised second edition of this book about theories of disease
distribution, in past and present societal and ecological context? Because the lived realities …

A number of commentaries have suggested that large studies are more reliable than smaller
studies and there is a growing interest in the analysis of “big data” that integrates information …

This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

The analysis of repeated measures or panel data allows control of some of the biases which
plague other observational studies, particularly unmeasured confounding. When this bias is …

Objective This position statement aimed to update the evidence-based position statement
published by The North American Menopause Society (NAMS) in 2010 regarding …

Objective: Our objective was to provide a scholarly review of the published literature on
menopausal hormonal therapy (MHT), make scientifically valid assessments of the available …

Background: The Women's Health Initiative randomized trial found greater coronary heart
disease (CHD) risk in women assigned to estrogen/progestin therapy than in those assigned …