Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

The ASK1-signalosome→ p38 MAPK and SAPK/JNK signaling networks promote
senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to …

COVID-19, caused by the SARS-CoV-2 virus, is a major source of morbidity and mortality
due to its inflammatory effects in the lungs and heart. The p38 MAPK pathway plays a crucial …

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …