Objective To collate all available evidence on the diagnostic value of laboratory tests for the
diagnosis of serious infections in febrile children in ambulatory settings. Design Systematic …

Fever in children is a common concern for parents and one of the most frequent presenting
complaints in emergency department visits, often involving non-pediatric emergency …

Background Efforts to develop an evidence-based approach to the evaluation and
management of young febrile infants have spanned more than 4 decades. 1 In the 1970s …

Importance In young febrile infants, serious bacterial infections (SBIs), including urinary tract
infections, bacteremia, and meningitis, may lead to dangerous complications. However …

BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and
laboratory parameters, including procalcitonin, was recently described as an accurate tool in …

Importance The procalcitonin (PCT) assay is an accurate screening test for identifying
invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are …

BACKGROUND AND OBJECTIVE: Prediction models tend to perform better on data on
which the model was constructed than on new data. This difference in performance is an …

Objective. Prospective studies were conducted to test the hypothesis that infants unlikely to
have serious bacterial infections (SBI) can be accurately identified by low risk criteria …

BACKGROUND AND OBJECTIVES: Variation in patient care or outcomes may indicate an
opportunity to improve quality of care. We evaluated the variation in testing, treatment …

Background: Management of febrile young infants suspected of having serious bacterial
infections has been a challenge for decades. The impact of changes in prenatal screening …