MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
MMPs in learning and memory and neuropsychiatric disorders
Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …
Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases
Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus
accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) …
accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) …
A glitch in the matrix: The role of extracellular matrix remodeling in opioid use disorder
Opioid use disorder (OUD) and deaths from drug overdoses have reached unprecedented
levels. Given the enormous impact of the opioid crisis on public health, a more thorough, in …
levels. Given the enormous impact of the opioid crisis on public health, a more thorough, in …
Variations in the expression of TIMP1, TIMP2 and TIMP3 in cutaneous melanoma with regression and their possible function as prognostic predictors
S Zurac, M Neagu, C Constantin… - Oncology …, 2016 - spandidos-publications.com
Regression in melanoma is a frequent biological event of uncertain prognostic value as the
lesion exhibits heterogeneous phenotypical features, both at the morphological and …
lesion exhibits heterogeneous phenotypical features, both at the morphological and …
Releasing addiction memories trapped in perineuronal nets
Drug addiction can be conceptualized at a basic level as maladaptive learning and memory.
Addictive substances elicit changes in brain circuitry involved in reward, cognition, and …
Addictive substances elicit changes in brain circuitry involved in reward, cognition, and …
The tetrapartite synapse: extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction
Synaptic plasticity has long been known to involve three key elements of neuropil, the
presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular …
presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular …
Neural ECM proteases in learning and synaptic plasticity
E Tsilibary, A Tzinia, L Radenovic… - Progress in Brain …, 2014 - Elsevier
Recent studies implicate extracellular proteases in synaptic plasticity, learning, and memory.
The data are especially strong for such serine proteases as thrombin, tissue plasminogen …
The data are especially strong for such serine proteases as thrombin, tissue plasminogen …
Matrix metalloproteinase‐9: A magic drug target in neuropsychiatry?
KT Kaczmarek, K Protokowicz… - Journal of …, 2023 - Wiley Online Library
Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …
of these conditions is very complex and combines genetic and environmental factors. The …
Signals from the fourth dimension regulate drug relapse
Despite the enormous societal burden of alcohol and drug addiction and abundant research
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …