Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

Matrix metalloproteinases (MMPs) are a group of over twenty proteases, operating chiefly
extracellularly to cleave components of the extracellular matrix, cell adhesion molecules as …

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus
accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) …

Opioid use disorder (OUD) and deaths from drug overdoses have reached unprecedented
levels. Given the enormous impact of the opioid crisis on public health, a more thorough, in …

Regression in melanoma is a frequent biological event of uncertain prognostic value as the
lesion exhibits heterogeneous phenotypical features, both at the morphological and …

Drug addiction can be conceptualized at a basic level as maladaptive learning and memory.
Addictive substances elicit changes in brain circuitry involved in reward, cognition, and …

Synaptic plasticity has long been known to involve three key elements of neuropil, the
presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular …

Recent studies implicate extracellular proteases in synaptic plasticity, learning, and memory.
The data are especially strong for such serine proteases as thrombin, tissue plasminogen …

Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …

Despite the enormous societal burden of alcohol and drug addiction and abundant research
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …