It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Metabolism of neoplastic cells is shifted toward high glucose uptake and enhanced lactate
production. Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A …

Metabolomic analysis has proven to be a useful tool in biomarker discovery and the
molecular classification of cancers. In order to find new biomarkers, and to better understand …

Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms
remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to …

Sertoli cells (SCs) provide structural and nutritional support for developing germ cells.
Normal glucose metabolism of SCs is necessary for spermatogenesis. Melatonin could …

The molecular mechanisms connecting cellular metabolism with differentiation remain
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …

Obesity incidence has pandemic proportions and is expected to increase even further.
Glucagon-like peptide-1 (GLP-1) based therapies are well-established pharmacological …

Sertoli cells play a pivotal role in the complex spermatogenesis process. This study aimed to
investigate the effects of PM 2.5 on Sertoli cells using the TM4 cell line and a real time whole …

Abstract Aims Sertoli cells (SCs) play an important role in the process of spermatogenesis.
SCs provide energy for germ cells (GCs) and themselves through glycolysis and fatty acid …