Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19
genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor …
genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor …
Pharmacogenetics to guide cardiovascular drug therapy
JD Duarte, LH Cavallari - Nature Reviews Cardiology, 2021 - nature.com
Over the past decade, pharmacogenetic testing has emerged in clinical practice to guide
selected cardiovascular therapies. The most common implementation in practice is …
selected cardiovascular therapies. The most common implementation in practice is …
Bivalirudin vs heparin with or without tirofiban during primary percutaneous coronary intervention in acute myocardial infarction: the BRIGHT randomized clinical trial
Importance The safety and efficacy of bivalirudin compared with heparin with or without
glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction (AMI) undergoing …
glycoprotein IIb/IIIa inhibitors in patients with acute myocardial infarction (AMI) undergoing …
Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention
LH Cavallari, CR Lee, AL Beitelshees… - JACC: Cardiovascular …, 2018 - jacc.org
Objectives: This multicenter pragmatic investigation assessed outcomes following clinical
implementation of CYP2C19 genotype–guided antiplatelet therapy after percutaneous …
implementation of CYP2C19 genotype–guided antiplatelet therapy after percutaneous …
Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis
The success of trials that have shown net clinical benefits of antithrombotic drugs as well as
the increasing prevalence of cardiovascular diseases in an ageing population have led to …
the increasing prevalence of cardiovascular diseases in an ageing population have led to …
Ticagrelor: pharmacokinetic, pharmacodynamic and pharmacogenetic profile: an update
R Teng - Clinical pharmacokinetics, 2015 - Springer
Despite advancements in treatments for acute coronary syndromes over the last 10 years,
they continue to be life-threatening disorders. Currently, the standard of treatment includes …
they continue to be life-threatening disorders. Currently, the standard of treatment includes …
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype‐Guided Antiplatelet Therapy
CYP2C19 genotype‐guided antiplatelet therapy following percutaneous coronary
intervention is increasingly implemented in clinical practice. However, challenges such as …
intervention is increasingly implemented in clinical practice. However, challenges such as …
CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association
NL Pereira, S Cresci, DJ Angiolillo, W Batchelor… - Circulation, 2024 - ahajournals.org
There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are
used to prevent ischemic outcomes in common diseases such as coronary and peripheral …
used to prevent ischemic outcomes in common diseases such as coronary and peripheral …
Pharmacogenomics in Asians: differences and similarities with other human populations
M Biswas, P Jinda, C Sukasem - Expert Opinion on Drug …, 2023 - Taylor & Francis
ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …
ethnicities. and clinical outcomes associated with these variants may also be substantially …
Clinical Utility of CYP2C19 Genotyping to Guide Antiplatelet Therapy in Patients With an Acute Coronary Syndrome or Undergoing Percutaneous Coronary …
MD Klein, AK Williams, CR Lee… - … , and Vascular Biology, 2019 - Am Heart Assoc
Current guidelines recommend dual antiplatelet therapy—a P2Y12 inhibitor (clopidogrel,
prasugrel, or ticagrelor) and aspirin—for patients undergoing percutaneous coronary …
prasugrel, or ticagrelor) and aspirin—for patients undergoing percutaneous coronary …