It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97%
of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been …

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined
pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we …

Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem
(iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and …

Stroke is an important disease with unmet clinical need. To uncover novel paths for
treatment, it is of critical importance to develop relevant laboratory models that may help to …

Abstract Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The …

Induced pluripotent stem cells (iPSCs) are terminally differentiated somatic cells that
differentiate into various cell types. iPSCs are expected to be used for disease modeling and …

Several neurodegenerative diseases are characterized by the accumulation of aggregated
misfolded proteins. These pathological agents have been suggested to propagate in the …

Dipeptide repeat proteins are a major pathogenic feature of C9orf72 amyotrophic lateral
sclerosis (C9ALS)/frontotemporal dementia (FTD) pathology, but their physiological impact …