EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …
Human PCNA structure, function, and interactions
A González-Magaña, FJ Blanco - Biomolecules, 2020 - mdpi.com
Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …
The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
JL Hsu, MC Hung - Cancer and Metastasis Reviews, 2016 - Springer
Breast cancer affects approximately 1 in 8 women, and it is estimated that over 246,660
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
women in the USA will be diagnosed with breast cancer in 2016. Breast cancer mortality has …
Forging ahead through darkness: PCNA, still the principal conductor at the replication fork
KN Choe, GL Moldovan - Molecular cell, 2017 - cell.com
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …
[HTML][HTML] PCNA, the maestro of the replication fork
GL Moldovan, B Pfander, S Jentsch - Cell, 2007 - cell.com
Inheritance requires genome duplication, reproduction of chromatin and its epigenetic
information, mechanisms to ensure genome integrity, and faithful transmission of the …
information, mechanisms to ensure genome integrity, and faithful transmission of the …
Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation
M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Regulation of PCNA–protein interactions for genome stability
N Mailand, I Gibbs-Seymour… - Nature reviews Molecular …, 2013 - nature.com
Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA
replication, providing a molecular platform that facilitates the myriad protein–protein and …
replication, providing a molecular platform that facilitates the myriad protein–protein and …
PCNA: a silent housekeeper or a potential therapeutic target?
SC Wang - Trends in pharmacological sciences, 2014 - cell.com
Proliferating cell nuclear antigen (PCNA) is known as a molecular marker for proliferation
given its role in replication. Three identical molecules of PCNA form a molecular sliding …
given its role in replication. Three identical molecules of PCNA form a molecular sliding …