Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …

Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …

Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq),
single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of transcriptomes and …

Mesenchymal stem/progenitor cells are essential for tissue development and repair
throughout life, but how they are maintained under chronic differentiation pressure is not …

Cold exposure triggers neogenesis in classic interscapular brown adipose tissue (iBAT) that
involves activation of β1-adrenergic receptors, proliferation of PDGFRA+ adipose tissue …

The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …

Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated
via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single …