Actions and regulation of ionotropic cannabinoid receptors
Almost three decades have passed since the identification of the two specific metabotropic
receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both …
receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both …
Transient receptor potential melastatin 8 channel (TRPM8) modulation: cool entryway for treating pain and cancer
MJ Pérez de Vega, I Gómez-Monterrey… - Journal of medicinal …, 2016 - ACS Publications
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous
cooling (< 28° C) and cooling compounds (menthol, icilin) and are implicated in sensing …
cooling (< 28° C) and cooling compounds (menthol, icilin) and are implicated in sensing …
Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma
The transient receptor potential (TRP) superfamily of ion channels has garnered significant
attention by the pharmaceutical industry. In particular, TRP channels showing high levels of …
attention by the pharmaceutical industry. In particular, TRP channels showing high levels of …
Effects of curcumin and curcumin analogues on TRP channels
M Nalli, G Ortar, AS Moriello, V Di Marzo… - Fitoterapia, 2017 - Elsevier
A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and
TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was …
TRPV1 channels. Twenty of them acted as good modulators of TRPA1 channels. None was …
Advances in the synthesis of heterocycles bearing an endocyclic urea moiety
AV Smolobochkin, AS Gazizov… - Russian Chemical …, 2021 - iopscience.iop.org
The review systematizes and summarizes data on the synthesis of structurally diverse cyclic
ureas published over the last 10 years. Saturated and unsaturated monocyclic ureas, as well …
ureas published over the last 10 years. Saturated and unsaturated monocyclic ureas, as well …
Tetrahydroisoquinoline-derived urea and 2, 5-diketopiperazine derivatives as selective antagonists of the transient receptor potential melastatin 8 (TRPM8) channel …
Tetrahydroisoquinoline derivatives containing embedded urea functions were identified as
selective TRPM8 channel receptor antagonists. Structure–activity relationships were …
selective TRPM8 channel receptor antagonists. Structure–activity relationships were …
Fluorescence-based assay for TRPV1 channels
AS Moriello, L De Petrocellis, RM Vitale - … Signaling: Methods and …, 2022 - Springer
The transient receptor potential vanilloid 1 ion channel (TRPV1) is a ligand-gated
nonselective calcium-permeant cation channel involved in the detection of a wide variety of …
nonselective calcium-permeant cation channel involved in the detection of a wide variety of …
Assay of TRPV1 receptor signaling
AS Moriello, L De Petrocellis - Endocannabinoid Signaling: Methods and …, 2016 - Springer
The transient receptor potential vanilloid-1 ion channel (TRPV1) is a non-selective ligand-
gated cation channel. It is an integrator of a wide variety of exogenous and endogenous …
gated cation channel. It is an integrator of a wide variety of exogenous and endogenous …
Dihydropyrimidin-2 (1H)-one and its analogues as a platform for the design and synthesis of new biologically active compounds
OP Shkurko, TG Tolstikova… - Russian Chemical …, 2016 - iopscience.iop.org
The data published mainly over two past decades on various types of biological activity of 5-
functionally substituted 3, 4-dihydropyrimidin-2-ones and their analogues, 2-thiones and 2 …
functionally substituted 3, 4-dihydropyrimidin-2-ones and their analogues, 2-thiones and 2 …
Natural compounds and synthetic drugs targeting the ionotropic cannabinoid members of transient receptor potential (TRP) channels
RM Vitale, AS Moriello, L De Petrocellis - 2020 - books.rsc.org
The transient receptor potential (TRP) channels are a superfamily of cation-permeable
channels found in yeast, invertebrates and vertebrates. The name comes from the first TRP …
channels found in yeast, invertebrates and vertebrates. The name comes from the first TRP …