OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …

Among critically ill patients, the diagnosis of bloodstream infection poses a major challenge.
Current standard bacterial identification based on blood culture platforms is intrinsically time …

Aims: To investigate the role of clinician burnout, demographic, and organizational
characteristics in predicting subjective and objective indicators of patient safety …

OBJECTIVES: Despite the established role of the critical care pharmacist on the ICU
multiprofessional team, critical care pharmacist workloads are likely not optimized in the …

Objective: To provide ICU clinicians with evidence-based guidance on safe medication use
practices for the critically ill. Data Sources: PubMed, Cochrane Database of Systematic …

Critically ill patients need life saving treatments and are often exposed to medications
requiring careful titration. The aim of this paper was to review systematically the research …

Background There is a need to identify effective interventions to minimize the threat posed
by medication administration errors (MAEs). Objective Our objective was to review and …

Opioids are the cornerstone of pain management; however, their use is associated with a
variety of adverse drug events (ADEs) ranging from nausea and vomiting to urinary retention …

Abstract Purpose Adverse drug events (ADEs) are harmful and occur with alarming
frequency in critically ill patients. Complex pharmacotherapy with multiple medications …

Introduction: Therapeutic hypothermia is being employed clinically due to its neuro-
protective benefits. Both critical illness and therapeutic hypothermia significantly affect drug …