Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by
intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis. Inflammation and …

Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …

These guidelines on the management of primary sclerosing cholangitis (PSC) were
commissioned by the British Society of Gastroenterology liver section. The guideline writing …

Primary sclerosing cholangitis is a chronic cholestatic liver disease that can shorten life and
may require liver transplantation. The cause is unknown, although it is commonly associated …

Primary sclerosing cholangitis (PSC) represents a major unmet medical need. In a phase II
double‐blind, placebo‐controlled study, we tested the safety and efficacy of cilofexor …

Abstract The Japanese Society of Gastroenterology revised the evidence-based clinical
practice guidelines for liver cirrhosis in 2015. Eighty-three clinical questions were selected …

Extensive population‐based studies are much needed to accurately establish epidemiology
and disease course in patients with primary sclerosing cholangitis (PSC). We aimed to …