The breakthrough of reprogramming human somatic cells was achieved in 2006 by the work
of Yamanaka and Takahashi. From this point, fibroblasts are the most commonly used …

Over the past decades, lentiviral vectors have evolved as a benchmark tool for stable gene
transfer into cells with a high replicative potential. Their relatively flexible genome and ability …

Telomere length in humans is associated with lifespan and severe diseases, yet the genetic
determinants of telomere length remain incompletely defined. Here we performed genome …

Differentiation of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers
an exciting avenue for the study of embryonic development and disease processes, for …

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced
pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to …

Progress in elucidating the molecular and cellular pathophysiology of neuropsychiatric
disorders has been hindered by the limited availability of living human brain tissue. The …

Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that
can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1 is required for …

Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer.
Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early …

It is becoming increasingly clear that the shape of the genome importantly influences
transcription regulation. Pluripotent stem cells such as embryonic stem cells were recently …

Background—Pluripotent stem cells (PSCs) offer a new paradigm for modeling genetic
cardiac diseases, but it is unclear whether mouse and human PSCs can truly model both …