Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates
cardiac gene expression. Here we show that the levels of an N-terminal proteolytically …

The adult human heart has an exceptional ability to alter its phenotype to adapt to changes
in environmental demand. This response involves metabolic, mechanical, electrical, and …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …

Background: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein
PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor …

Background Right ventricular (RV) function is the most important prognostic factor for
pulmonary arterial hypertension (PAH) patients. The progressive increase of pulmonary …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …