Plasmodium sporozoites are the product of a complex developmental process in the
mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Background Characterization of the innate immune repertoire of extant cnidarians is of both
fundamental and applied interest-it not only provides insights into the basic …

Perforin-like proteins are expressed by many bacterial and protozoan pathogens, yet little is
known about their function or mode of action. Here, we describe Toxoplasma perforin-like …

Pore‐forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In
eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey …

Proteins containing membrane attack complex/perforin (MACPF) domains play important
roles in vertebrate immunity, embryonic development, and neural-cell migration. In …

The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …

The invasive stages (zoites) of most apicomplexan parasites are polarised cells that use
their actinomyosin-powered gliding motility or “glideosome” system to move over surfaces …

The causative agent of malaria, Plasmodium, has to undergo complex developmental
transitions and survive attacks from the mosquito's innate immune system to achieve …

Gene expression in Plasmodium parasites undergoes significant changes in each
developmental stage, but the transcription factors (TFs) regulating these changes have not …