Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Fifteen years of genetic research in Parkinson's disease (PD) have led to the identification of
several monogenic forms of the disorder and of numerous genetic risk factors increasing the …

The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Parkinson's disease is the most common neurodegenerative movement disorder. Mutations
in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease …

To date, molecular genetic analyses have identified over 500 distinct DNA variants in five
disease genes associated with familial Parkinson disease; α‐synuclein (SNCA), parkin …

Several biochemical abnormalities have been described in the brains of patients with
Parkinson's disease (PD), including oxidative stress and mitochondrial dysfunction. The …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …

Pathological data from autopsies genotyped for Parkinson's disease (PD)‐related mutations
in alpha‐synuclein, Parkin, PINK1, DJ1, LRRK2, and glucocerebrosidase have accumulated …