Parametric mapping techniques provide a non-invasive tool for quantifying tissue alterations
in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR) …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Fibrosis is associated with organ failure and high mortality and is commonly characterized
by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in …

Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial
myocardial collagen network that occur in response to cardiac ischaemic insults, systemic …

Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac
development and disease. However, our understanding of the importance of these …

Despite available therapy, mortality and readmission rates within 60–90 days of discharge
for patients hospitalized with heart failure (HF) approach 15% and 30%, respectively. This …

Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions,
known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the …

Interstitial fibrosis plays a key role in the development and progression of heart failure. Here,
we show that an enzyme that crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential …

Background Myocardial fibrosis (MF) in noninfarcted myocardium may be an interstitial
disease pathway that confers vulnerability to hospitalization for heart failure, death, or both …

Engineered heart tissue (EHT) has ample potential as a model for in vitro tissue modeling or
tissue regeneration. Using 3D cell printing technology, various hydrogels have been utilized …