The mammalian ovary from genesis to revelation
MA Edson, AK Nagaraja, MM Matzuk - Endocrine reviews, 2009 - academic.oup.com
Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …
which allow continuation of the species, and the generation of bioactive molecules, primarily …
GATA transcription factors in development and disease
M Tremblay, O Sanchez-Ferras, M Bouchard - Development, 2018 - journals.biologists.com
The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …
development, playing complex and widespread roles in cell fate decisions and tissue …
Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …
reproduction. Ovarian development requires the combination of germ cells and several …
Genetic regulation of mammalian gonad development
S Eggers, T Ohnesorg, A Sinclair - Nature Reviews Endocrinology, 2014 - nature.com
Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …
differentiates into either a mature testis or an ovary. This process is dependent on activation …
At the crossroads of fate—somatic cell lineage specification in the fetal gonad
E Rotgers, A Jørgensen, HHC Yao - Endocrine reviews, 2018 - academic.oup.com
The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …
Mammalian sex determination—insights from humans and mice
S Eggers, A Sinclair - Chromosome research, 2012 - Springer
Disorders of sex development (DSD) are congenital conditions in which the development of
chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad …
chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad …
FOXL2: a central transcription factor of the ovary
A Georges, A Auguste, L Bessiere… - Journal of …, 2014 - jme.bioscientifica.com
Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially
expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are …
expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are …
[HTML][HTML] Testis development requires the repression of Wnt4 by Fgf signaling
SA Jameson, YT Lin, B Capel - Developmental biology, 2012 - Elsevier
The bipotential gonad expresses genes associated with both the male and female
pathways. Adoption of the male testicular fate is associated with the repression of many …
pathways. Adoption of the male testicular fate is associated with the repression of many …
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2
Sex determination of the gonads begins with fate specification of gonadal supporting cells
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …
Cell fate commitment during mammalian sex determination
YT Lin, B Capel - Current opinion in genetics & development, 2015 - Elsevier
The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All
secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on …
secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on …