The mammalian ovary from genesis to revelation

MA Edson, AK Nagaraja, MM Matzuk - Endocrine reviews, 2009 - academic.oup.com
Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

GATA transcription factors in development and disease

M Tremblay, O Sanchez-Ferras, M Bouchard - Development, 2018 - journals.biologists.com
The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

MDP Smela, CC Kramme, PRJ Fortuna, JL Adams… - Elife, 2023 - elifesciences.org
An in vitro model of human ovarian follicles would greatly benefit the study of female
reproduction. Ovarian development requires the combination of germ cells and several …

Genetic regulation of mammalian gonad development

S Eggers, T Ohnesorg, A Sinclair - Nature Reviews Endocrinology, 2014 - nature.com
Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

At the crossroads of fate—somatic cell lineage specification in the fetal gonad

E Rotgers, A Jørgensen, HHC Yao - Endocrine reviews, 2018 - academic.oup.com
The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Mammalian sex determination—insights from humans and mice

S Eggers, A Sinclair - Chromosome research, 2012 - Springer
Disorders of sex development (DSD) are congenital conditions in which the development of
chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad …

FOXL2: a central transcription factor of the ovary

A Georges, A Auguste, L Bessiere… - Journal of …, 2014 - jme.bioscientifica.com
Forkhead box L2 (FOXL2) is a gene encoding a forkhead transcription factor preferentially
expressed in the ovary, the eyelids and the pituitary gland. Its germline mutations are …

[HTML][HTML] Testis development requires the repression of Wnt4 by Fgf signaling

SA Jameson, YT Lin, B Capel - Developmental biology, 2012 - Elsevier
The bipotential gonad expresses genes associated with both the male and female
pathways. Adoption of the male testicular fate is associated with the repression of many …

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

B Nicol, SA Grimm, F Chalmel, E Lecluze… - Nature …, 2019 - nature.com
Sex determination of the gonads begins with fate specification of gonadal supporting cells
into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification …

Cell fate commitment during mammalian sex determination

YT Lin, B Capel - Current opinion in genetics & development, 2015 - Elsevier
The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All
secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on …