Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

The NF-κB signalling pathway is a major signalling cascade involved in the regulation of
inflammation and innate immunity. It is also increasingly recognised as a crucial player in …

Gene expression profiling has revealed that diffuse large B cell lymphoma (DLBCL) consists
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell …

NF-κB is a family of related, dimeric transcription factors that are readily activated in cells by
signals associated with stress or pathogens. These factors are critical to host defense, as …

The pathogenesis and etiology of Hodgkin's disease, a common human malignant
lymphoma, is still unresolved. As a unique characteristic, we have identified constitutive …

Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate
that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB. We …

The c-rel proto-oncogene, which is expressed predominantly in hemopoietic cells encodes a
subunit of the NF-kappa B-like family of transcription factors. In mice with an inactivated c-rel …

Activation of the inducible transcription factor NF‐kappa B involves removal of the inhibitory
subunit I kappa B‐alpha from a latent cytoplasmic complex. It has been reported that I kappa …

NF-κB is a DNA-binding protein complex that transduces a variety of activating signals from
the cytoplasm to specific sets of target genes. To understand the preferential recruitment of …

Activation of NF-κB following genotoxic stress allows time for DNA-damage repair and
ensures cell survival accounting for acquired chemoresistance, an impediment to effective …