Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …

Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood,,. Here we show …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation
of inflammatory responses is associated with most human diseases. Reactive oxygen …