Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …

KCl has long been used as a convenient stimulus to bypass G protein-coupled receptors
(GPCR) and activate smooth muscle by a highly reproducible and relatively “simple” …

▪ Abstract Phosphorylation of Ser19 on the 20-kDa regulatory light chain of myosin II
(MLC20) by Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) is essential for …

Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in
vascular diseases. The RhoA/ROCK signaling pathway is now well recognized to mediate …

Two mechanisms are proposed to account for the inhibition of myosin phosphatase (MP)
involved in Ca2+ sensitization of vascular muscle, ie, phosphorylation of either MYPT1, a …

Evidence indicates that both the Rho/Rho kinase signaling pathway and reactive oxygen
species (ROS) such as superoxide and H2O2 are involved in the pathogenesis of …

Myosin phosphatase (MLCP) plays a critical regulatory role in the Ca2+ sensitivity of myosin
phosphorylation and smooth muscle contraction. It has been suggested that phosphorylation …