Clinical progress and advanced research of red blood cells based drug delivery system

Y Li, F Raza, Y Liu, Y Wei, R Rong, M Zheng, W Yuan… - Biomaterials, 2021 - Elsevier
Red blood cells (RBCs) are biocompatible carriers that can be employed to deliver different
bioactive substances. In the past few decades, many strategies have been developed to …

Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications

S Zhang, Q Fu, Y Zhang, J Pan, L Zhang… - Acta Pharmacologica …, 2021 - nature.com
Nano drug-delivery systems (DDS) may significantly improve efficiency and reduce toxicity
of loaded drugs, but a few nano-DDS are highly successful in clinical use. Unprotected …

Red blood cells for drug delivery

J Yan, J Yu, C Wang, Z Gu - Small Methods, 2017 - Wiley Online Library
Red blood cells (RBCs), or erythrocytes, have been promising endogenous candidates for
drug delivery for more than four decades. Armed with a better understanding of the diverse …

Lipid insertion enables targeted functionalization of paclitaxel-loaded erythrocyte membrane nanosystem by tumor-penetrating bispecific recombinant protein

H Chen, H Sha, L Zhang, H Qian, F Chen… - International journal …, 2018 - Taylor & Francis
Background There is currently much interest in cancer cell targeting and tumor penetrating
for research and therapeutic purposes. Purpose To improve targeting delivery of antitumor …

[HTML][HTML] Recent strategies on targeted delivery of thrombolytics

T Huang, N Li, J Gao - Asian journal of pharmaceutical sciences, 2019 - Elsevier
Thrombus formed in blood vessel is a progressive process, which would lead to life-
threatening thrombotic diseases such as ischemic stroke. Unlike other diseases, the …

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

AT Anastasiadi, VZ Arvaniti, KE Hudson… - Protein & …, 2024 - academic.oup.com
Eukaryotic cells are defined as cells containing distinct nuclei and other membranous
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …

Combination of drugs and carriers in drug delivery technology and its development

Y Du, B Chen - Drug design, development and therapy, 2019 - Taylor & Francis
The development of drug-loading technology will bring new and rapid development to the
treatment of diseases. At present, drug delivery by nanoparticles, erythrocyte, and platelet …

[HTML][HTML] Natural cell based biomimetic cellular transformers for targeted therapy of digestive system cancer

X Tang, D Li, Y Gu, Y Zhao, A Li, F Qi, J Liu - Theranostics, 2022 - ncbi.nlm.nih.gov
Digestive system cancer is the most common cause of cancer death in the world. Although
cancer treatment options are increasingly diversified, the mortality rate of malignant cancer …

Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

K Berikkhanova, E Taigulov, Z Bokebaev, A Kusainov… - Heliyon, 2024 - cell.com
Scientific organizations worldwide are striving to create drug delivery systems that provide a
high local concentration of a drug in pathological tissue without side effects on healthy …

[HTML][HTML] Red blood cells in biology and translational medicine: natural vehicle inspires new biomedical applications

X Zhang, Y Lin, J Xin, Y Zhang, K Yang, Y Luo… - Theranostics, 2024 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are the most abundant cell type in the blood, and play a critical role
in oxygen transport. With the development of nanobiotechnology and synthetic biology …