Metabolomics as a tool to investigate HIV/TB co-infection

C Liebenberg, L Luies, AA Williams - Frontiers in molecular …, 2021 - frontiersin.org
The HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) and
tuberculosis (TB) pandemics are perpetuated by a significant global burden of HIV/TB co …

HIV/HAART-associated oxidative stress is detectable by metabonomics

AA Williams, LJ Sitole, D Meyer - Molecular BioSystems, 2017 - pubs.rsc.org
Chronic human immunodeficiency virus (HIV) infection, separately and in combination with
highly active antiretroviral therapy (HAART) is closely associated with oxidative stress (OS) …

The metabolic consequences of HIV/TB co-infection

C Herbert, L Luies, DT Loots, AA Williams - BMC Infectious Diseases, 2023 - Springer
Background The synergy between the human immunodeficiency virus (HIV) and
Mycobacterium tuberculosis during co-infection of a host is well known. While this synergy is …

Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy

NC Peltenburg, JC Schoeman, J Hou, F Mora… - Scientific Reports, 2018 - nature.com
The HIV-human metabolic relationship is a complex interaction convoluted even more by
antiretroviral therapy (cART) and comorbidities. The ability of cART to undo the HIV induced …

Mid-ATR-FTIR spectroscopic profiling of HIV/AIDS sera for novel systems diagnostics in global health

L Sitole, F Steffens, TPJ Krüger… - Omics: a journal of …, 2014 - liebertpub.com
Global health, whether in developed or developing countries, is in need of robust systems
diagnostics for major diseases, such as HIV/AIDS, impacting the world populations. Fourier …

Analysis of urinary organic acids by gas chromatography tandem mass spectrometry method for metabolic profiling applications

T Mouskeftara, C Virgiliou, G Theodoridis… - … of Chromatography A, 2021 - Elsevier
A sensitive, accurate and precise method was developed for the quantification of a large
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …

Multi-platform metabonomics unravel amino acids as markers of HIV/combination antiretroviral therapy-induced oxidative stress

LJ Sitole, F Tugizimana, D Meyer - Journal of Pharmaceutical and …, 2019 - Elsevier
Infection by the human immunodeficiency virus (HIV) elicits an immune response wherein
neutrophils produce reactive oxygen species (ROS) to defend against pathogen invasion …

Metabonomic analysis of HIV-infected biofluids

LJ Sitole, AA Williams, D Meyer - Molecular Biosystems, 2013 - pubs.rsc.org
Monitoring the progression of HIV infection to full-blown acquired immune deficiency
syndrome (AIDS) and assessing responses to treatment will benefit greatly from the …

The Th1/Th2/Th17 cytokine profile of HIV-infected individuals: a multivariate cytokinomics approach

A Williams, F Steffens, C Reinecke, D Meyer - Cytokine, 2013 - Elsevier
HIV infection causes the dysregulation of cytokine production. A cytokinomics approach
employing cytometric bead array (CBA) technology, flow cytometry and multivariate analysis …

A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status

TR McKnight, HAI Yoshihara, LJ Sitole… - Molecular …, 2014 - pubs.rsc.org
Individuals infected with the human immunodeficiency virus (HIV) often suffer from
concomitant metabolic complications. Treatment with antiretroviral therapy has also been …