[PDF][PDF] Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
History, discovery, and classification of lncRNAs
J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
[PDF][PDF] Establishing cerebral organoids as models of human-specific brain evolution
Direct comparisons of human and non-human primate brains can reveal molecular
pathways underlying remarkable specializations of the human brain. However, chimpanzee …
pathways underlying remarkable specializations of the human brain. However, chimpanzee …
[PDF][PDF] Human-specific NOTCH2NL genes expand cortical neurogenesis through delta/notch regulation
IK Suzuki, D Gacquer, R Van Heurck, D Kumar… - Cell, 2018 - cell.com
The cerebral cortex underwent rapid expansion and increased complexity during recent
hominid evolution. Gene duplications constitute a major evolutionary force, but their impact …
hominid evolution. Gene duplications constitute a major evolutionary force, but their impact …
[HTML][HTML] Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
[PDF][PDF] Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
[PDF][PDF] The cellular and molecular landscapes of the developing human central nervous system
The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …
neurodevelopmental features are highly derived. Building the human CNS requires the …
Long non-coding RNAs: new players in cell differentiation and development
A Fatica, I Bozzoni - Nature Reviews Genetics, 2014 - nature.com
Genomes of multicellular organisms are characterized by the pervasive expression of
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …
different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel …
Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study
Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …
[PDF][PDF] Enhancer evolution across 20 mammalian species
The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …
genome, but we lack a comprehensive understanding of regulatory evolution in mammals …