Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence
PK Lin, GE Davis - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …
[HTML][HTML] Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function
L Ducoli, M Detmar - Developmental Cell, 2021 - cell.com
The lymphatic vascular system acts as the major transportation highway of tissue fluids, and
its activation or impairment is associated with a wide range of diseases. There has been …
its activation or impairment is associated with a wide range of diseases. There has been …
Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing
Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1%(refs.,). Despite
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …
[HTML][HTML] De novo mutations in CHD4, an ATP-dependent chromatin remodeler gene, cause an intellectual disability syndrome with distinctive dysmorphisms
K Weiss, PA Terhal, L Cohen, M Bruccoleri… - The American Journal of …, 2016 - cell.com
Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP-dependent chromatin
remodeler involved in epigenetic regulation of gene transcription, DNA repair, and cell cycle …
remodeler involved in epigenetic regulation of gene transcription, DNA repair, and cell cycle …
The CHD4-related syndrome: a comprehensive investigation of the clinical spectrum, genotype–phenotype correlations, and molecular basis
K Weiss, HP Lazar, A Kurolap, AF Martinez… - Genetics in …, 2020 - nature.com
Abstract Purpose Sifrim–Hitz–Weiss syndrome (SIHIWES) is a recently described
multisystemic neurodevelopmental disorder caused by de novo variants in CHD4. In this …
multisystemic neurodevelopmental disorder caused by de novo variants in CHD4. In this …
Proinflammatory mediators, IL (interleukin)-1β, TNF (tumor necrosis factor) α, and thrombin directly induce capillary tube regression
GM Koller, C Schafer, SS Kemp… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: In this work, we examine the molecular basis for capillary tube regression and
identify key proregressive factors, signaling pathways, and pharmacological antagonists of …
identify key proregressive factors, signaling pathways, and pharmacological antagonists of …
[HTML][HTML] Sequencing overview of Ewing sarcoma: a journey across genomic, epigenomic and transcriptomic landscapes
LGL Sand, K Szuhai, PCW Hogendoorn - International journal of …, 2015 - mdpi.com
Ewing sarcoma is an aggressive neoplasm occurring predominantly in adolescent
Caucasians. At the genome level, a pathognomonic EWSR1-ETS translocation is present …
Caucasians. At the genome level, a pathognomonic EWSR1-ETS translocation is present …
Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature
P Delgado-Olguín, LT Dang, D He, S Thomas… - …, 2014 - journals.biologists.com
Maintenance of vascular integrity is required for embryogenesis and organ homeostasis.
However, the gene expression programs that stabilize blood vessels are poorly understood …
However, the gene expression programs that stabilize blood vessels are poorly understood …
DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression
JD Price, S Lindtner, A Ypsilanti, F Binyameen… - …, 2022 - journals.biologists.com
In the developing subpallium, the fate decision between neurons and glia is driven by
expression of Dlx1/2 or Olig1/2, respectively, two sets of transcription factors with a mutually …
expression of Dlx1/2 or Olig1/2, respectively, two sets of transcription factors with a mutually …
[HTML][HTML] Covalent modifications of histone H3K9 promote binding of CHD3
Chromatin remodeling is required for genome function and is facilitated by ATP-dependent
complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core …
complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core …