Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …

The lymphatic vascular system acts as the major transportation highway of tissue fluids, and
its activation or impairment is associated with a wide range of diseases. There has been …

Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1%(refs.,). Despite
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …

Chromodomain helicase DNA-binding protein 4 (CHD4) is an ATP-dependent chromatin
remodeler involved in epigenetic regulation of gene transcription, DNA repair, and cell cycle …

Abstract Purpose Sifrim–Hitz–Weiss syndrome (SIHIWES) is a recently described
multisystemic neurodevelopmental disorder caused by de novo variants in CHD4. In this …

Objective: In this work, we examine the molecular basis for capillary tube regression and
identify key proregressive factors, signaling pathways, and pharmacological antagonists of …

Ewing sarcoma is an aggressive neoplasm occurring predominantly in adolescent
Caucasians. At the genome level, a pathognomonic EWSR1-ETS translocation is present …

Maintenance of vascular integrity is required for embryogenesis and organ homeostasis.
However, the gene expression programs that stabilize blood vessels are poorly understood …

In the developing subpallium, the fate decision between neurons and glia is driven by
expression of Dlx1/2 or Olig1/2, respectively, two sets of transcription factors with a mutually …

Chromatin remodeling is required for genome function and is facilitated by ATP-dependent
complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core …