Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding
the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of …

Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic,. Among the seven eukaryotic phosphoinositides the best studied species …

Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized
membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus …