Systematic reviews seek to identify all research that meets the eligibility criteria. However,
this goal can be compromised by 'non‐reporting bias'. The convincing evidence for the …

Mendelian randomization (MR) uses genetic variants as instrumental variables to infer
whether a risk factor causally affects a health outcome. Meta‐analysis has been used …

Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on
how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered …

Cognitive behavior therapy (CBT) is by far the most examined type of psychological
treatment for depression and is recommended in most treatment guidelines. However, no …

Objective Meta-analysis is of fundamental importance to obtain an unbiased assessment of
the available evidence. In general, the use of meta-analysis has been increasing over the …

Microbiome-wide association studies on large population cohorts have highlighted
associations between the gut microbiome and complex traits, including type 2 diabetes …

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …

Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …

Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …

Mendelian randomization (MR) uses genetic data to probe questions of causality in
epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent …