[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

[HTML][HTML] Idiopathic pulmonary fibrosis: pathogenesis and management

G Sgalla, B Iovene, M Calvello, M Ori, F Varone… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

[HTML][HTML] Cellular senescence mediates fibrotic pulmonary disease

MJ Schafer, TA White, K Iijima, AJ Haak… - Nature …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …

[HTML][HTML] SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis

D Wendisch, O Dietrich, T Mari, S von Stillfried… - Cell, 2021 - cell.com
Summary COVID-19-induced" acute respiratory distress syndrome"(ARDS) is associated
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …

Sexual health implications of COVID-19 pandemic

C Pennanen-Iire, M Prereira-Lourenço… - Sexual medicine …, 2021 - academic.oup.com
Introduction A novel coronavirus (COVID-19) reached pandemic levels by March 11th, 2020,
with a destructive impact across socioeconomic domains and all facets of global health, but …

The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis

PL Molyneaux, MJ Cox, SAG Willis-Owen… - American journal of …, 2014 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown
cause that leads to respiratory failure and death within 5 years of diagnosis. Overt …

Immune mechanisms in pulmonary fibrosis

S Kolahian, IE Fernandez, O Eickelberg… - American journal of …, 2016 - atsjournals.org
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …

Interplay between the lung microbiome and lung cancer

Q Mao, F Jiang, R Yin, J Wang, W Xia, G Dong, W Ma… - Cancer letters, 2018 - Elsevier
The human microbiome confers benefits or disease susceptibility to the human body through
multiple pathways. Disruption of the symbiotic balance of the human microbiome is …

Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study

MLK Han, Y Zhou, S Murray, N Tayob, I Noth… - The Lancet …, 2014 - thelancet.com
Background The role of the lung microbiome in the pathogenesis of idiopathic pulmonary
fibrosis is unknown. We investigated whether unique microbial signatures were associated …

The microbiome in respiratory medicine: current challenges and future perspectives

R Faner, O Sibila, A Agustí… - European …, 2017 - Eur Respiratory Soc
The healthy lung has previously been considered to be a sterile organ because standard
microbiological culture techniques consistently yield negative results. However, culture …