Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …

Major depressive disorder (MDD) is a common psychiatric illness with a wide range of
symptoms such as mood decline, loss of interest, and feelings of guilt and worthlessness …

Background and purpose Cerebral small vessel disease (CSVD) is a clinically commonly-
seen slow-progressing cerebral vascular disease. As a classic Chinese formula for the …

Depression in older individuals is a common complex mood disorder with high comorbidity
of both psychiatric and physical diseases, associated with high disability, cognitive decline …

Background There remain few efficacious treatments for bipolar depression, which
dominates the course of bipolar disorder (BD). Despite multiple studies reporting …

Treatment-Resistant Late-Life Depression - Psychiatric Clinics Skip to Main Content
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Ketamine infusion therapy can produce fast-acting antidepressant effects in patients with
major depressive disorder (MDD). Yet, how single and repeated ketamine treatment induces …

This review highlights that depression is a growing health problem for the individual, and
because of its high frequency in most societies, a growing burden on health care budgets …

Background Despite the impact of depression in terms of personal suffering and
socioeconomic burden, most currently available treatment options are often ineffective. A …

Depression is common in older individuals and is associated with high disability and
increased mortality, yet the factors predicting late-life depression (LLD) are poorly …