High‐aspect‐ratio nanostructured surfaces as biological metamaterials

SG Higgins, M Becce… - Advanced …, 2020 - Wiley Online Library
Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Recent advances in the stereolithographic three-dimensional printing of ceramic cores: Challenges and prospects

J Li, X An, J Liang, Y Zhou, X Sun - Journal of Materials Science & …, 2022 - Elsevier
The increasing demand for geometrically complex structures—specifically, higher-inlet-
temperature turbine blades for the fifth-generation or other high-generation machines of …

Surface roughness and substrate stiffness synergize to drive cellular mechanoresponse

Y Hou, L Yu, W Xie, LC Camacho, M Zhang, Z Chu… - Nano …, 2019 - ACS Publications
Material surface topographic features have been shown to be crucial for tissue regeneration
and surface treatment of implanted devices. Many biomaterials were investigated with …

The regulatory functionality of exosomes derived from hUMSCs in 3D culture for Alzheimer's disease therapy

L Yang, Y Zhai, Y Hao, Z Zhu, G Cheng - Small, 2020 - Wiley Online Library
Reducing amyloid‐β (Aβ) accumulation could be a potential therapeutic approach for
Alzheimer's disease (AD). Particular functional biomolecules in exosomes vested by the …

Hierarchical hydrogel composite interfaces with robust mechanical properties for biomedical applications

Y Zhu, Q Zhang, X Shi, D Han - Advanced Materials, 2019 - Wiley Online Library
Cells sense and respond to a wide range of external signals, including chemical signals,
topography, and interface mechanics, via interactions with the extracellular matrix (ECM) …

Recent advances of designing dynamic surfaces to regulate cell adhesion

X Zhao, L Jin, H Shi, W Tong, D Gorin… - Colloid and Interface …, 2020 - Elsevier
Cells are always living in a dynamic microenvironment and are able to respond to stimuli
and modulate their functions. Cell adhesion is the fundamental of almost all cell behaviors …

Bio-instructive materials for musculoskeletal regeneration

T Gonzalez-Fernandez, P Sikorski, JK Leach - Acta biomaterialia, 2019 - Elsevier
The prevalence and cost of disorders affecting the musculoskeletal system are predicted to
rise significantly in the coming years due to the aging global population and the increase of …

An In Situ Reversible Heterodimeric Nanoswitch Controlled by Metal‐Ion–Ligand Coordination Regulates the Mechanosensing and Differentiation of Stem Cells

H Kang, K Zhang, HJ Jung, B Yang, X Chen… - Advanced …, 2018 - Wiley Online Library
In situ and cytocompatible nanoswitching by external stimuli is highly appealing for
reversibly regulating cellular adhesion and functions in vivo. Here, a heterodimeric …

Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing‐dependent …

SHD Wong, B Yin, B Yang, S Lin, R Li… - Advanced Functional …, 2019 - Wiley Online Library
The nanoscale anisotropic patterns of bioactive ligands in the extracellular matrix regulate
cell adhesion behaviors. However, the mechanisms of such regulation remain unclear …

Controlled nanoscale topographies for osteogenic differentiation of mesenchymal stem cells

CR Pedrosa, D Arl, P Grysan, I Khan… - … applied materials & …, 2019 - ACS Publications
Nanotopography with length scales of the order of extracellular matrix elements offers the
possibility of regulating cell behavior. Investigation of the impact of nanotopography on cell …