Down syndrome (DS) is one of the most common chromosomal abnormalities. Because of
medical advances and improvements in overall medical care, the median survival of …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute
leukemias. Survival rates have increased over the past few decades to~ 70%, due to …

Children with constitutional trisomy 21 (cT 21, D own S yndrome, DS) are at a higher risk for
both myeloid and B‐lymphoid leukaemias. The myeloid leukaemias are often preceded by a …

Newborns and children with Down syndrome (DS) often present with congenital transient
leukemia and have an increased risk of acute myeloid leukemia and acute lymphoblastic …

Constitutional trisomy 21 inherent to Down syndrome (DS) is associated with several
hematological disorders occurring at different ages. Neonates with DS may present with …

Learning Objectives Evaluate malignancies for which children with Down syndrome are at
increased and decreased risk in order to screen appropriately. Analyze the clinical and …

Background Children with Down syndrome have an increased risk of developing acute
lymphoblastic leukemia and a poor tolerance of methotrexate. This latter problem is …

Down syndrome (DS) associates with impaired brain functions, but the underlying
mechanism (s) are yet unclear. The “gene dosage” hypothesis predicts that in DS …

PURPOSE: To test whether female subjects in families with cleft lip and/or palate (CL/P)
have an increased risk of breast cancer. METHODS: By using the Danish Facial Cleft …