The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances
carotid body (CB) chemosensory responses to hypoxia and produces autonomic …

Mammalian carotid bodies are the main peripheral arterial chemoreceptors, strategically
located at the bifurcation of the common carotid artery. When stimulated these receptors …

The control of breathing depends critically on sensory inputs to the central pattern generator
of the brainstem, arising from peripheral arterial chemoreceptors located principally in the …

The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic
organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen …

The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO 2,
PCO 2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory …