Tryptophan (Trp) holds a unique place in biology for a multitude of reasons. It is the largest
of all twenty amino acids in the translational toolbox. Its side chain is indole, which is …

Constitutive α-helical membrane proteins (MPs) 1 are assembled in membranes by means
of a translocation/insertion process that involves the translocon complex (1). After release …

The determination of basic probability assignment (BPA) is a crucial issue in the application
of Dempster–Shafer evidence theory. Classification is a process of determining the class …

HELIQUEST calculates the physicochemical properties and amino acid composition of an α-
helix and screens databank to identify protein segments possessing similar features. This …

We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …

The Orientations of Proteins in Membranes (OPM) database provides a collection of
transmembrane, monotopic and peripheral proteins from the Protein Data Bank whose …

Background Alpha-helical transmembrane (TM) proteins are involved in a wide range of
important biological processes such as cell signaling, transport of membrane-impermeable …

In many rhodopsin-like G-protein-coupled receptors, agonist binding to a cluster of aromatic
residues in TM6 may promote receptor activation by altering the configuration of the TM6 Pro …

Proline residues in the transmembrane (TM) α-helices of integral membrane proteins have
long been suspected to play a key role for helix packing and signal transduction by inducing …

Hydropathy plot methods form a cornerstone of membrane protein research, especially in
the early stages of biochemical and structural characterization. Membrane Protein Explorer …