Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

OA is a painful joint disease that predominantly affects the elderly. Pain is the primary
symptom of OA, and it can present as either intermittent or constant. OA pain mechanisms …

Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains
incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic
treatment for numerous conditions, including osteoarthritis and lower back pain. This review …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However in the adult …