DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …

In nature, specific antibodies can be generated as a result of an adaptive selection and
expansion of lymphocytes with suitable protein binding properties. We attempted to mimic …

DNA-encoded chemical libraries are increasingly used in pharmaceutical research because
they enable the rapid discovery of synthetic protein ligands. Here we explored whether …

Highlights•DNA-encoded chemical libraries: powerful means for hit identification in
pharma.•Link between the chemical building block and an amplifiable genetic …

DNA-encoded chemical libraries (DELs) have become a powerful technology platform in
drug discovery. Dual-pharmacophore DELs display two sets of small molecules at the …

Abstract In 1992, Brenner and Lerner hypothesized that individual chemical transformations
could be encoded in DNA, allowing the rapid synthesis and screening of large collections of …

Conspectus In the past two decades, a DNA-encoded chemical library (DEL or DECL) has
emerged and has become a major technology platform for ligand discovery in drug …

DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that
enable facile screening and identification of bio‐macromolecule binders. The successful …