Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature Reviews Drug Discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications

MQ Lian, WH Chng, J Liang, HQ Yeo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) represent a diverse class of lipid bilayer membrane vesicles
released by both animal and plant cells. These ubiquitous vesicles are involved in …

Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy

J Zhang, C Ji, H Zhang, H Shi, F Mao, H Qian, W Xu… - Science …, 2022 - science.org
Neutrophils are the most abundant innate immune cells in human circulation; however, their
derived exosomes have been rarely studied for tumor treatment. Here, we reported that …

Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment

Q Gao, J Feng, W Liu, C Wen, Y Wu, Q Liao… - Advanced drug delivery …, 2022 - Elsevier
The therapeutic limitations such as insufficient efficacy, drug resistance, metastasis, and
undesirable side effects are frequently caused by the long duration monotherapy based on …

Engineering macrophages for cancer immunotherapy and drug delivery

Y Xia, L Rao, H Yao, Z Wang, P Ning… - Advanced …, 2020 - Wiley Online Library
Macrophages play an important role in cancer development and metastasis.
Proinflammatory M1 macrophages can phagocytose tumor cells, while anti‐inflammatory M2 …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Z Weng, B Zhang, C Wu, F Yu, B Han, B Li… - Journal of hematology & …, 2021 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids,
RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential …

Exosome-based smart drug delivery tool for cancer theranostics

R Kar, R Dhar, S Mukherjee, S Nag… - ACS biomaterials …, 2023 - ACS Publications
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles
derived from the plasma membrane. The main activity of exosomes is cellular …

Isolation and characterization of extracellular vesicle subpopulations from tissues

R Crescitelli, C Lässer, J Lötvall - Nature protocols, 2021 - nature.com
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells.
Most EV studies have been performed by using cell lines or body fluids, but the number of …

Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …