Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

GB Frisoni, M Boccardi, F Barkhof, K Blennow… - The Lancet …, 2017 - thelancet.com
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …

Alzheimer's disease

P Scheltens, K Blennow, MMB Breteler, B De Strooper… - The Lancet, 2016 - thelancet.com
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

[HTML][HTML] Gut microbiota composition is related to AD pathology

BJH Verhaar, HMA Hendriksen, FA de Leeuw… - Frontiers in …, 2022 - frontiersin.org
Introduction Several studies have reported alterations in gut microbiota composition of
Alzheimer's disease (AD) patients. However, the observed differences are not consistent …

[HTML][HTML] Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

IMW Verberk, E Thijssen, J Koelewijn, K Mauroo… - Alzheimer's research & …, 2020 - Springer
Background Blood-based biomarkers for Alzheimer's disease (AD) might facilitate
identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation …

Blood-brain barrier leakage in patients with early Alzheimer disease

HJ Van De Haar, S Burgmans, JFA Jansen… - Radiology, 2016 - pubs.rsna.org
Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …

The lifespan human connectome project in aging: an overview

SY Bookheimer, DH Salat, M Terpstra, BM Ances… - Neuroimage, 2019 - Elsevier
Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study

A Topiwala, CL Allan, V Valkanova, E Zsoldos… - bmj, 2017 - bmj.com
Objectives To investigate whether moderate alcohol consumption has a favourable or
adverse association or no association with brain structure and function. Design …

[HTML][HTML] Identification of Alzheimer's disease using a convolutional neural network model based on T1-weighted magnetic resonance imaging

JB Bae, S Lee, W Jung, S Park, W Kim, H Oh, JW Han… - Scientific reports, 2020 - nature.com
The classification of Alzheimer's disease (AD) using deep learning methods has shown
promising results, but successful application in clinical settings requires a combination of …

Progress toward standardized diagnosis of vascular cognitive impairment: guidelines from the vascular impairment of cognition classification consensus study

OA Skrobot, SE Black, C Chen, C DeCarli… - Alzheimer's & …, 2018 - Wiley Online Library
Introduction Progress in understanding and management of vascular cognitive impairment
(VCI) has been hampered by lack of consensus on diagnosis, reflecting the use of multiple …

[HTML][HTML] Amsterdam dementia cohort: performing research to optimize care

WM Van Der Flier, P Scheltens - Journal of Alzheimer's …, 2018 - content.iospress.com
The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated
to combine both patient care and research. Together, to date, all patients forming the …