Background Despite advances in early detection and therapies, cancer is still one of the
most common causes of death worldwide. Since each tumor is unique, there is a need to …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …

Inflammasomes are innate immune mechanisms that promote inflammation by activating the
protease caspase‐1. Active caspase‐1 induces pyroptosis, a necrotic form of regulated cell …

Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune
responses need to be further identified. By functionally screening the lncRNAs in …

Sirt3, as a major mitochondrial nicotinamide adenine dinucleotide (NAD)-dependent
deacetylase, is required for mitochondrial metabolic adaption to various stresses. However …

Autophagy was considered as a double-edged sword that might cooperate, aggravate, or
antagonize apoptosis. We found that the sonodynamic therapy (SDT) in low dosage induced …