Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the
preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss
of midbrain dopaminergic neurons in association with aggregation of α-synuclein. Oxidative …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Parkinson's disease (PD) is a gradually progressing neurodegenerative condition that is
marked by a loss of motor coordination along with non-motor features. Although the precise …

Parkinson's disease (PD) is a neurodegenerative condition characterized by the dopamine
(DA) neuronal loss in the substantia nigra. PD impairs motor controls symptoms such as …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and multiple sclerosis are characterized by a chronic and …