Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

Skeletal tissue development and regeneration in mammals are intricate, multistep, and
highly regulated processes. Various signaling pathways have been implicated in the …

Achieving satisfactory reconstruction of bone remains an important goal in orthopedic and
dental conditions such as bone trauma, osteoporosis, arthritis, osteonecrosis, and …

Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown
adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose …