Pharmacogenetics of Gilbert's syndrome
CP Strassburg - Pharmacogenomics, 2008 - Taylor & Francis
Gilbert's syndrome is characterized by mild unconjugated nonhemolytic hyperbilirubinemia,
which does not lead to hepatic inflammation, fibrosis, chronic liver disease or liver failure …
which does not lead to hepatic inflammation, fibrosis, chronic liver disease or liver failure …
Exploring the genetic architecture of neonatal hyperbilirubinemia
JF Watchko, Z Lin - Seminars in Fetal and Neonatal Medicine, 2010 - Elsevier
The potential for genetic variation to modulate neonatal hyperbilirubinemia risk is
increasingly being recognized. In particular, polymorphisms across three genes involved in …
increasingly being recognized. In particular, polymorphisms across three genes involved in …
Gilbert and Crigler Najjar syndromes: an update of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene mutation database
G Canu, A Minucci, C Zuppi, E Capoluongo - Blood Cells, Molecules, and …, 2013 - Elsevier
UGT1A1 enzyme defects are responsible of both Gilbert syndrome (GS) and Crigler–Najjar
syndrome (CNS). GS depends on a variant TATAA element (which contains two extra TA …
syndrome (CNS). GS depends on a variant TATAA element (which contains two extra TA …
Complex multifactorial nature of significant hyperbilirubinemia in neonates
JF Watchko, Z Lin, RH Clark, AS Kelleher… - …, 2009 - publications.aap.org
OBJECTIVE: To determine whether glucose-6-phosphate dehydrogenase (G6PD), uridine-
diphosphoglucuronosyltransferase 1A1 (UGT1A1), and hepatic solute carrier organic anion …
diphosphoglucuronosyltransferase 1A1 (UGT1A1), and hepatic solute carrier organic anion …
Molecular pathogenesis of Gilbert's syndrome: decreased TATA-binding protein binding affinity of UGT1A1 gene promoter
TY Hsieh, TY Shiu, SM Huang, HH Lin… - Pharmacogenetics …, 2007 - journals.lww.com
Objectives Gilbert's syndrome is a congenital, nonhemolytic, unconjugated
hyperbilirubinemia. The most common genotype of Gilbert's syndrome is the homozygous …
hyperbilirubinemia. The most common genotype of Gilbert's syndrome is the homozygous …
Variability and function of family 1 uridine-5′-diphosphate glucuronosyltransferases (UGT1A)
CP Strassburg, S Kalthoff, U Ehmer - Critical reviews in clinical …, 2008 - Taylor & Francis
The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins
includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants …
includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants …
UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China
H Yang, F Lin, Z Chen, L Zhang, JX Xu, YH Wu, JY Gu… - BMC pediatrics, 2021 - Springer
Background Neonatal hyperbilirubinemia causing jaundice is common in East Asian
population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) …
population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) …
UGT1A1 genetic analysis as a diagnostic aid for individuals with unconjugated hyperbilirubinemia
JM Skierka, KE Kotzer, SA Lagerstedt, DJ O'Kane… - The journal of …, 2013 - Elsevier
OBJECTIVE: To assess the clinical utility of UGT1A1 genetic testing and describe the
spectrum and prevalence of UGT1A1 variations identified in pediatric unconjugated …
spectrum and prevalence of UGT1A1 variations identified in pediatric unconjugated …
Polymorphisms of UGT1A1* 6, UGT1A1* 27 & UGT1A1* 28 in three major ethnic groups from Malaysia
Methods: A total of 306 healthy unrelated volunteers were screened for UGT1A1* 28,
UGT1A1* 6 and UGT1A1* 27. Blood samples (5 ml) were obtained from each subject and …
UGT1A1* 6 and UGT1A1* 27. Blood samples (5 ml) were obtained from each subject and …
Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?
CP Strassburg - Drug metabolism reviews, 2010 - Taylor & Francis
Gilbert's syndrome is characterized by mild unconjugated nonhemolytic hyperbilirubinemia,
without hepatic inflammation, fibrosis, chronic liver disease, or liver failure. It is readily …
without hepatic inflammation, fibrosis, chronic liver disease, or liver failure. It is readily …