Pathways to neuronal injury and apoptosis in HIV-associated dementia

M Kaul, GA Garden, SA Lipton - Nature, 2001 - nature.com
Abstract Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …

Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

The role of excitotoxicity in neurodegenerative disease: implications for therapy

A Doble - Pharmacology & therapeutics, 1999 - Elsevier
Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

HS Chen, JW Pellegrini, SK Aggarwal… - Journal of …, 1992 - Soc Neuroscience
Excessive activation of NMDA receptors is thought to mediate the calcium-dependent
neurotoxicity associated with hypoxic-ischemic brain injury, trauma, epilepsy, and several …

Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma

EB Dreyer, D Zurakowski, RA Schumer… - Archives of …, 1996 - jamanetwork.com
Objective: To explore the possibility that the excitatory amino acid glutamate might be
associated with the disease process of glaucoma, which is characterized by the death of …

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

TM Dawson, SH Snyder - Journal of Neuroscience, 1994 - Soc Neuroscience
In a remarkably brief period of time, NO and CO have been recognized as putative
neurotransmitters. These two novel messenger molecules have greatly expanded the …

A novel neuronal messenger molecule in brain: the free radical, nitric oxide

TM Dawson, VL Dawson… - Annals of Neurology …, 1992 - Wiley Online Library
Understanding of the organization and function of a newly identified neuronal messenger
molecule, nitric oxide, has progressed rapidly. Nitric oxide synthase has been purified and …

Infectious agents and neurodegeneration

G De Chiara, ME Marcocci, R Sgarbanti, L Civitelli… - Molecular …, 2012 - Springer
A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …

Determinant factors of livelihood diversification: Evidence from Ethiopia

GW Kassie, S Kim, FP Fellizar Jr - Cogent Social Sciences, 2017 - Taylor & Francis
Ethiopia's agricultural productivity is considered low despite the presence of various
agricultural policies. These policies focus mainly on on-farm agricultural development to the …

Molecular basis of glutamate toxicity in retinal ganglion cells

NJ Sucher, SA Lipton, EB Dreyer - Vision research, 1997 - Elsevier
Loss of retinal ganglion cells (RGCs) is a hallmark of many ophthalmic diseases including
glaucoma, retinal ischemia due to central artery occlusion, anterior ischemic optic …