The genetic basis for adult onset glaucoma: Recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
Clinical implications of recent advances in primary open-angle glaucoma genetics
H Choquet, JL Wiggs, AP Khawaja - Eye, 2020 - nature.com
Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …
have accelerated the discovery of genes and genomic regions contributing to primary open …
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an
increasingly common cause of blindness. This genome-wide association meta-analysis in …
increasingly common cause of blindness. This genome-wide association meta-analysis in …
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma
Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the
disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is …
disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is …
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study: cross sectional study
MPY Chan, DC Broadway, AP Khawaja, JLY Yip… - bmj, 2017 - bmj.com
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the
prevalence of glaucoma. Design Community based cross sectional observational study …
prevalence of glaucoma. Design Community based cross sectional observational study …
[PDF][PDF] Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology
Genome-wide association studies (GWASs) require accurate cohort phenotyping, but expert
labeling can be costly, time intensive, and variable. Here, we develop a machine learning …
labeling can be costly, time intensive, and variable. Here, we develop a machine learning …
[HTML][HTML] Systemic medication and intraocular pressure in a British population: the EPIC-Norfolk Eye Study
AP Khawaja, MPY Chan, DC Broadway… - Ophthalmology, 2014 - Elsevier
Objective To determine the association between systemic medication use and intraocular
pressure (IOP) in a population of older British men and women. Design Population-based …
pressure (IOP) in a population of older British men and women. Design Population-based …
[HTML][HTML] The association between serum lipids and intraocular pressure in 2 large United Kingdom cohorts
Purpose Serum lipids are modifiable, routinely collected blood test features associated with
cardiovascular health. We examined the association of commonly collected serum lipid …
cardiovascular health. We examined the association of commonly collected serum lipid …
[HTML][HTML] Retinal vasculometry associations with cardiometabolic risk factors in the european prospective investigation of cancer—norfolk study
Purpose To examine associations between retinal vessel morphometry and cardiometabolic
risk factors in older British men and women. Design Retinal imaging examination as part of …
risk factors in older British men and women. Design Retinal imaging examination as part of …
Visual acuity, self-reported vision and falls in the EPIC-Norfolk Eye study
Purpose To examine the relationship between visual acuity (VA) and self-reported vision
(SRV) in relation to falls in 8317 participants of the European Prospective Investigation into …
(SRV) in relation to falls in 8317 participants of the European Prospective Investigation into …