Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Background and purpose Sickle cell disease (SCD) is a collection of rare inherited blood
disorders affecting approximately 100,000 people in the US and 20–25 million people …

Pain in sickle cell disease (SCD) is associated with increased morbidity, mortality, and high
health care costs. Although episodic acute pain is the hallmark of this disorder, there is an …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Introduction Sickle cell disease, one of the world's most prevalent Mendelian disorders, is a
chronic hemolytic anemia punctuated by acute vasoocclusive events. Both hemolysis and …

Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell
disease. Asthma is common in children with sickle-cell disease and is associated with …

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by polymerization
of hemoglobin S upon deoxygenation that results in the formation of rigid sickled-shaped red …

Thalassemia and sickle cell disease (SCD) are disorders of hemoglobin that affect millions
of people worldwide. The carrier states for these diseases arose as common, balanced …

All patients with HbSS (SCA) share the same genetic mutation but the clinical phenotype is
variable and difficult to predict early in life. A reliable severity predictor would be invaluable …