Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

Co-polymer poly (lactic-co-glycolic acid)(PLGA) nanotechnology has been developed for
many years and has been approved by the US FDA for the use of drug delivery, diagnostics …

Among the emerging subunit vaccines are recombinant protein-and synthetic peptide-based
vaccine formulations. However, proteins and peptides have a low intrinsic immunogenicity …

Peptide and protein-based cancer vaccines usually fail to elicit efficient immune responses
against tumors. However, delivery of these peptides and proteins as components within …

abstract Due to the excellent safety profile of poly (D, L-lactide-co-glycolide)(PLGA) particles
in human, and their biodegradability, many studies have focused on the application of PLGA …

Development of safe and effective cancer vaccine formulation is a primary focus in the field
of cancer immunotherapy. The recognition of the crucial role of dendritic cells (DCs) in …

Current research and development of antigens for vaccination often center on purified
recombinant proteins, viral subunits, synthetic oligopeptides or oligosaccharides, most of …

Dendritic cells play a central role in antigen presentation and generation of cytotoxic T
lymphocyte (CTL) response required for anticancer vaccination. The review focuses on use …

The development of high-purity antigens promotes the urgent need of novel adjuvant with
the capability to trigger high levels of immune response. Polyinosinic-polycytidylic (Poly (I …

Dendritic cells (DCs) rely on glycolysis for their energy needs to induce pro-inflammatory
antigen-specific immune responses. Therefore, inhibiting DC glycolysis, while presenting …