Background The treatment for snakebites is early administration of antivenom, which can be
highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the …

Structure predictions have matched the accuracy of experimental structures from close
homologues, providing suitable models for molecular replacement phasing. Even in …

Density modification is a standard step to provide a route for routine structure solution by any
experimental phasing method, with single-wavelength or multi-wavelength anomalous …

In accidents involving Crotalus snakes, the crotoxin complex (CTX) plays lethal action due to
its neurotoxic activity. On the other hand, CTX have potential biotechnological application …

ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient
uptake of nutrients that are not produced de novo or improve the energy balance. The cell …

Crystallography at low resolution must determine the atomic model from less experimental
observations, which is challenging in the absence of a model. In addition, model bias is …

Abstract Phospholipases A 2 (PLA 2 s) are found in almost every venomous snake family. In
snakebites, some PLA 2 s can quickly cause local myonecrosis, which may lead to …

Snakebite envenoming is still a worrying health problem in countries under development,
being recognized as a neglected disease by the World Health Organization. In Latin …

ABSTRACT UDP-N-acetylglucosamine (UDP-GlcNAc), the main product of the hexosamine
biosynthetic pathway, is an important metabolite in protozoan parasites since its sugar …

Proteins isolated from natural sources can be composed of a mixture of isoforms with similar
physicochemical properties that coexist in the final steps of purification. Yet, even where …