Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Mitochondrial dynamics and mitophagy have been linked to cardiovascular and
neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin …

Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …

Rationale: Mitochondrial Ca2+ uptake is essential for the bioenergetic feedback response
through stimulation of Krebs cycle dehydrogenases. Close association of mitochondria to …

Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Human pluripotent stem cell-derived cardiomyocytes (CMs) are a promising tool for cardiac
cell therapy. Although transplantation of induced pluripotent stem cell (iPSC)-derived CMs …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–
demand balance necessary for its contractile function in response to physiological …