Tendons and ligaments are fibrous connective tissues vital to the transmission of force and
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …

Tendons are cable-like connective tissues that transfer both active and passive forces
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …

Limb development has long served as a model system for coordinated spatial patterning of
progenitor cells. Here, we identify a population of naive limb progenitors and show that they …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate …

Positional information driving limb muscle patterning is contained in connective tissue
fibroblasts but not in myogenic cells. Limb muscles originate from somites, while connective …

Introduction. Regeneration of fibrochondrocytes is essential for the healing of the tendon‐
bone interface (TBI), which is similar to the formation of neurogenic heterotopic ossification …

The enthesis, a fibrocartilaginous transition between tendon and bone, is necessary for force
transfer from muscle to bone to produce joint motion. The enthesis is prone to injury due to …

Although previous RNA sequencing methods have been widely used in orthopedic research
and have provided ideas for therapeutic strategies, the specific mechanisms of some …

The transcriptional regulators underlying induction and differentiation of dense connective
tissues such as tendon and related fibrocartilaginous tissues (meniscus and annulus …

Entheses transmit force from tendons and ligaments to the skeleton. Regional organization
of enthesis extracellular matrix (ECM) generates differences in stiffness required for force …